5-MAPB

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What is 5-MAPB?

5-MAPB, short for 5-(2-Methylaminopropyl)benzofuran, is a synthetic compound belonging to the phenethylamine and amphetamine chemical classes. This research chemical has gained attention in scientific circles due to its structural similarity to MDMA (3,4-Methylenedioxymethamphetamine), commonly known as ecstasy.

Chemical Structure and Properties

5-MAPB features a benzofuran ring system connected to an alkyl aminopropane side chain. This unique molecular arrangement contributes to its psychoactive effects. The compound exists as a white crystalline powder, typically in the form of hydrochloride salt. Its solubility in water and organic solvents makes it suitable for various research applications.

Pharmacological Profile

As a research chemical, 5-MAPB's pharmacological profile is not fully elucidated. However, studies suggest it acts primarily on the serotonin, dopamine, and norepinephrine systems. Its mechanism of action involves increasing the release and inhibiting the reuptake of these neurotransmitters, particularly serotonin. This activity pattern is reminiscent of MDMA, though with potentially distinct nuances in effect and duration.

Legal Status and Research Applications

The legal status of 5-MAPB varies globally, with many countries classifying it as a controlled substance. Its use is primarily restricted to scientific research, where it serves as a valuable tool for studying the effects of entactogens and the broader class of phenethylamines on brain chemistry and behavior.

Molecular Composition and Structure

5-MAPB, short for 1-(1-benzofuran-5-yl)-N-methylpropan-2-amine, belongs to the phenethylamine and amphetamine classes of compounds. Its chemical structure closely resembles that of MDMA (3,4-Methylenedioxymethamphetamine), with a benzofuran ring replacing MDMA's methylenedioxy ring. This subtle structural difference contributes to 5-MAPB's unique pharmacological profile.

Mechanism of Action

The primary mechanism of action for 5-MAPB involves its interaction with monoamine neurotransmitters in the brain. It acts as a potent releaser and reuptake inhibitor of serotonin, norepinephrine, and dopamine. This triple action on these key neurotransmitters is responsible for its psychoactive effects.

Pharmacokinetics and Metabolism

When ingested, 5-MAPB is rapidly absorbed into the bloodstream. The compound undergoes hepatic metabolism, primarily through the cytochrome P450 enzyme system. Its metabolites are then excreted through urine. The duration of effects can vary, but typically lasts between 4 to 6 hours, with residual effects potentially persisting for several hours afterward.

Understanding the chemical structure and pharmacology of 5-MAPB is crucial for researchers investigating its potential applications and assessing its safety profile. However, it's important to note that as a research chemical, comprehensive long-term studies on its effects in humans are limited.